Table 7. Correlation between combined PIK3CA-pAKT-pER status and clinicopathological factors and prognosis in postmenopausal women.
| PIK3CA wild-type (n = 73) | PIK3CA mutant (n = 71) | ||||||
|---|---|---|---|---|---|---|---|
| Type | Type A | Type B | Type C | Type D | Type E | Type F | Type G |
| pAKT | high | high | low | low | high | low | low |
| pER | low | high | low | high | low/high | low | high |
| No. of patients | 8 (11%) | 13 (18%) | 26 (36%) | 26 (36%) | 9 (13%) | 21 (30%) | 41 (58%) |
| Age (years), mean ± SD (range) | 63.8 ± 8.0 (52–78) |
59.4 ± 6.6 (50–74) |
62.3 ± 9.4 (42–80) |
62.4 ± 7.8 (50–77) |
57.2 ± 6.8d (47–71) |
64.4 ± 5.9 (52–74) |
65.0 ± 9.0d (48–84) |
| BMI, mean ± SD | 23.4 ± 4.2 | 23.2 ± 2.4 | 26.1 ± 4.1 | 24.0 ± 5.3 | 21.5 ± 3.0 | 25.3 ± 4.2 | 23.6 ± 4.1 |
| Tumor size (T), median (range) |
2 (1–3) | 1 (1–2) | 2 (1–3) | 1 (1–2) | 1 (1–3) | 1 (1–3)e | 1 (1–2)e |
| No. of positive lymph nodes, median (range) |
1 (0–6) | 0 (0–1) | 0 (0–4) | 0 (0–10) | 0 (0–1) | 0 (0–10) | 0 (0–7) |
| Tumor grade, median (range) |
3 (2–3)a | 2 (1–2)a | 2 (1–3) | 2 (1–3) | 2 (1–2) | 2 (1–3) | 2 (1–3) |
| Ki67 LI (%), median (range) |
18.8 (6.8–39.8) |
19.5 (3.5–52.7) |
9.1 (2.0–31.7) |
11.0 (2.0–31.4) |
5.5 (2.0–27.6) |
11.5 (0.1–34.1) |
7.0 (0.4–35.3) |
| ER (%), median (range) |
90 (20–100) |
90 (10–100) |
80 (10–100) |
90 (20–100) |
60 (50–100) |
90 (20–100)f |
90 (40–100)f |
| PgR (%), median (range) |
20 (0–100) |
5 (0–80)b |
30 (0–100)b |
10 (0–70) |
5 (0–30) |
20 (0–90) |
20 (0–100) |
| AR (%), mean ± SD (range) | 31.3 ± 25.7 (5–80) |
42.5 ± 32.6 (1–95) |
23.4 ± 21.8 (0–80) |
38.3 ± 32.5 (0–95) |
45.2 ± 39.6 (1–95) |
29.8 ± 28.0g (0–95) |
50.2 ± 34.0g (1–100) |
| VDR (%), median (range) |
7.5 (0–50) |
20 (0–50)c |
5 (0–30)c |
15 (0–80) |
20 (0–50) |
25 (0–40) |
15 (0–50) |
| No. of patients with recurrence | |||||||
| within 2 years | 3 (38%) | 0 | 2 (8%) | 0 | 0 | 1 (5%) | 0 |
| within 5 years | 4 (50%) | 2 (15%) | 3 (12%) | 0 | 0 | 2 (10%) | 0 |
| within 10 years | 4 (50%) | 3 (23%) | 4 (15%) | 2 (8%) | 0 | 3 (14%) | 0 |
LI: labeling index; pAKT: AKT phospho-Ser473; pER: ERα phospho-Ser167.
aP = 0.0083 by Steel’s test.
bP = 0.047 by Steel’s test.
cP = 0.032 by Steel’s test.
dP = 0.0095 by Dunnett’s test.
eP = 0.0094 by Steel’s test.
fP = 0.023 by Steel’s test.
gP = 0.024 by Dunnett’s test.