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. 2018 Apr 3;9(25):17770–17796. doi: 10.18632/oncotarget.24880

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Copyright: © 2018 Özenver et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Cytotoxicity of Aloe-emodin (A), emodin (B), rhein (C) and physcion (D) towards sensitive CCRF-CEM and multidrug-resistant P-glycoprotein-expressing CEM/ADR5000 acute lymphoblastic cells and of Aloe-emodin as the most cytotoxic compound towards HCT116 (p53^+/+) colon cancer cells and its knockout clone HCT116 (p53^-/-) (E), HEK293 human embryonic kidney cells and its resistant counterpart HEK293/ ABCB5 transfected with a cDNA of ABCB5 (F), MDA-MB-231-pcDNA3 breast cancer cells and its resistant subline MDA-MB-231-BCRP clone 23 (G), and U87. MG glioblastoma cells and its transfected subline U87.MGΔEGFR, respectively (H). Mean values ± SD of three independent experiments are shown.