Table 1. Summary of CXCR3 ligands expression in various disease.
Disease | Ligands | Receptors | Cell type effected | References |
---|---|---|---|---|
Autoimmune Liver disease |
CXCL9/10 | CXCR3 | Hepatocytes | Nishioji K. et al. Clin. & Exp. Immunol. 2001; 123:271–9. |
Alzheimer’s Disease | CXCL10 | CXCR3 | Astrocytes | Xia M.Q. et al. J. Neuroimmunol, 2000; 108:227–35. |
Hodgkin’s | CXCL9/10 | CXCR3 | Hodgkin RS cells | Ohshima K. et al. Int. J. Cancer, 2002; 98:567–72. |
Central Nervous System |
CXCL9/10 | CXCR3 | T cells | Liu MT. et al. J. Immunol. 2001; 166:1790–5. |
Grave’s | CXCL9/10 | CXCR3 | Glomerular | Romagnani P. et al. J. Pathol, 2002; 161:195–206. |
Asthma | CXCL10 | CXCR3 | T cells | Medoff B.D. et al. J. Immunol. 2002; 168:5278–86. |
Glomerulonephritis | CXCL9/10 | CXCR3 | Mesangial | Romagnani P. et al. J. Am. Soc. Neprol. 10; 2518–26. |
Multiple Sclerosis | CXCL9/10/11 | CXCR3 | Astrocytes | Salmaggi A. et al. J. Inter. Cyto. Res. 2002; 22:631–40. |
Bronchiolotis | CXCL10 | CXCR3 | Mononuclear | Belperio J.A, et al. J. Immunol. 2002; 169:1037–49. |
Mucosal Inflammation | CXCL9/10/11 | CXCR3 | Keratinocytes | Flier J, et al. J. Pathol. 2001; 194:398–405. |
Lupus | CXCL10 | CXCR3 | T cells | Rotondi M. et al. Endocr. Rev. 2007; 28:492–520. |
Diabetes | CXCL10 | CXCR3 | T cells | Shiozawa F. et al. Arthritis Res Ther. 2004; 6:R78–R86. |
Interstitial cystitis | CXCL9, CXCL10 | CXCR3 | T cells | Singh UP. et al. I. Immunol. 2003; 1:171(3):1401–1406. |
Colitis | CXCL10 | CXCR3 | T cells | Singh UP. et al. Plos One 21; 8(11) e79751. |
Summary of the various cell types in autoimmune diseases mediated by CXCR3 and its ligands.