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. 2018 Apr 3;9(25):17928–17936. doi: 10.18632/oncotarget.24730

Table 1. Summary of CXCR3 ligands expression in various disease.

Disease Ligands Receptors Cell type effected References
Autoimmune
Liver disease
CXCL9/10 CXCR3 Hepatocytes Nishioji K. et al. Clin. & Exp. Immunol. 2001; 123:271–9.
Alzheimer’s Disease CXCL10 CXCR3 Astrocytes Xia M.Q. et al. J. Neuroimmunol, 2000; 108:227–35.
Hodgkin’s CXCL9/10 CXCR3 Hodgkin RS cells Ohshima K. et al. Int. J. Cancer, 2002; 98:567–72.
Central Nervous
System
CXCL9/10 CXCR3 T cells Liu MT. et al. J. Immunol. 2001; 166:1790–5.
Grave’s CXCL9/10 CXCR3 Glomerular Romagnani P. et al. J. Pathol, 2002; 161:195–206.
Asthma CXCL10 CXCR3 T cells Medoff B.D. et al. J. Immunol. 2002; 168:5278–86.
Glomerulonephritis CXCL9/10 CXCR3 Mesangial Romagnani P. et al. J. Am. Soc. Neprol. 10; 2518–26.
Multiple Sclerosis CXCL9/10/11 CXCR3 Astrocytes Salmaggi A. et al. J. Inter. Cyto. Res. 2002; 22:631–40.
Bronchiolotis CXCL10 CXCR3 Mononuclear Belperio J.A, et al. J. Immunol. 2002; 169:1037–49.
Mucosal Inflammation CXCL9/10/11 CXCR3 Keratinocytes Flier J, et al. J. Pathol. 2001; 194:398–405.
Lupus CXCL10 CXCR3 T cells Rotondi M. et al. Endocr. Rev. 2007; 28:492–520.
Diabetes CXCL10 CXCR3 T cells Shiozawa F. et al. Arthritis Res Ther. 2004; 6:R78–R86.
Interstitial cystitis CXCL9, CXCL10 CXCR3 T cells Singh UP. et al. I. Immunol. 2003; 1:171(3):1401–1406.
Colitis CXCL10 CXCR3 T cells Singh UP. et al. Plos One 21; 8(11) e79751.

Summary of the various cell types in autoimmune diseases mediated by CXCR3 and its ligands.