Table 2.
Adjusted associations between phenols, phthalate metabolites and behavior at 3 y among boys of the EDEN mother–child cohort ( to 520 mother–son pairs, depending of the subscale).
| Emotional symptoms | Conduct problems | Peer relationship problems | Hyperactivity–inattention problems | Prosocial behavior | Externalizing behavior | Internalizing behavior | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IRR | 95% CI | IRR | 95% CI | IRR | 95% CI | IRR | 95% CI | IRR | 95% CI | IRR | 95% CI | IRR | 95% CI | |
| Phenols | ||||||||||||||
| 1.02 | (0.98, 1.06) | 1.01 | (0.99, 1.04) | 0.99 | (0.95, 1.03) | 1.00 | (0.98, 1.03) | 1.00 | (0.98, 1.03) | 1.01 | (0.99, 1.03) | 1.00 | (0.97, 1.03) | |
| Bisphenol A | 1.01 | (0.94, 1.09) | 1.03 | (0.98, 1.08) | 1.11 | (1.03, 1.20)** | 1.04 | (0.99, 1.08) | 1.05 | (0.99, 1.10) | 1.03 | (0.99, 1.07) | 1.06 | (1.00, 1.12)* |
| Benzophenone-3 | 1.00 | (0.96, 1.03) | 0.99 | (0.97, 1.01) | 1.01 | (0.98, 1.05) | 1.01 | (0.99, 1.03) | 0.99 | (0.96, 1.01) | 1.00 | (0.98, 1.02) | 1.00 | (0.98, 1.03) |
| Triclosan | 1.02 | (1.00, 1.04)* | 1.01 | (1.00, 1.03)* | 1.00 | (0.98, 1.03) | 1.01 | (1.00, 1.03) | 1.01 | (0.99, 1.03) | 1.01 | (1.00, 1.03)* | 1.01 | (0.99, 1.03) |
| 1.00 | (0.97, 1.04) | 0.99 | (0.97, 1.02) | 0.99 | (0.95, 1.02) | 0.98 | (0.96, 1.00) | 0.97 | (0.94, 1.00)** | 0.99 | (0.97, 1.01) | 1.00 | (0.97, 1.03) | |
| Phthalates | ||||||||||||||
| MEP | 1.03 | (0.97, 1.08) | 1.00 | (0.97, 1.04) | 0.97 | (0.92, 1.03) | 1.00 | (0.97, 1.03) | 0.99 | (0.95, 1.03) | 1.00 | (0.97, 1.03) | 1.00 | (0.96, 1.04) |
| MnBP | 1.06 | (1.00, 1.12)** | 1.01 | (0.97, 1.04) | 1.06 | (1.00, 1.12)** | 0.99 | (0.95, 1.02) | 0.99 | (0.95, 1.03) | 1.00 | (0.97, 1.03) | 1.06 | (1.01, 1.11)** |
| MiBP | 0.97 | (0.90, 1.05) | 1.00 | (0.96, 1.05) | 1.05 | (0.98, 1.13) | 0.95 | (0.91, 1.00)** | 0.99 | (0.94, 1.05) | 0.97 | (0.94, 1.01) | 1.01 | (0.95, 1.07) |
| MCPP | 1.03 | (0.96, 1.11) | 0.98 | (0.94, 1.03) | 1.04 | (0.97, 1.12) | 0.96 | (0.92, 1.00)* | 0.95 | (0.90, 1.00)* | 0.97 | (0.93, 1.01) | 1.04 | (0.98, 1.10) |
| MBzP | 1.02 | (0.96, 1.09) | 1.00 | (0.97, 1.04) | 1.07 | (1.01, 1.13)** | 0.98 | (0.94, 1.01) | 0.97 | (0.93, 1.02) | 0.99 | (0.96, 1.02) | 1.04 | (1.00, 1.09)* |
| MCOP | 1.02 | (0.95, 1.10) | 1.01 | (0.97, 1.06) | 0.99 | (0.92, 1.06) | 0.98 | (0.94, 1.03) | 1.00 | (0.95, 1.05) | 1.00 | (0.96, 1.04) | 1.01 | (0.95, 1.06) |
| MCNP | 1.01 | (0.95, 1.07) | 0.99 | (0.95, 1.03) | 1.00 | (0.94, 1.06) | 0.97 | (0.93, 1.01) | 0.98 | (0.94, 1.03) | 0.98 | (0.95, 1.01) | 1.00 | (0.95, 1.05) |
| 1.04 | (0.97, 1.11) | 0.99 | (0.95, 1.04) | 1.05 | (0.98, 1.12) | 0.97 | (0.93, 1.01) | 0.99 | (0.94, 1.04) | 0.98 | (0.94, 1.02) | 1.04 | (0.99, 1.10) | |
Note: CI, confidence interval; , molecular sum of di(2-ethylhexyl) phthalate metabolites; , molecular sum of 2,4 and 2,5-dichlorophenols; IRR, incidence rate ratio; MBzP, monobenzyl phthalate; MCNP, monocarboxynonyl phthalate; MCOP, monocarboxyoctyl phthalate; MCPP, mono(3-carboxypropyl) phthalate; MEP, monoethyl phthalate; MiBP. mono-isobutyl phthalate, MnBP, mono-n-butyl phthalate; , molecular sum of methyl, ethyl, propyl, and butyl parabens. Associations adjusted for recruitment center, maternal age, parity, parental education, breastfeeding duration, household income, smoking during pregnancy, maternal psychological difficulties during pregnancy, and child age at assessment. IRR are reported for a doubling in biomarkers concentrations.
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