. 2017 Sep 26;125(9):097020. doi: 10.1289/EHP1302

Table 5.

Adjusted odds ratios (aORs) and 95% confidence intervals (95% CIs) for the association between polybrominated biphenyl (PBB)-153, polychlorinated biphenyl (PCB)-118, PCB-138, PCB-153, PCB-180, and $Σ PCB$ (nanograms/milliliter) and thyroid disease among Michigan males, 2004–2015.

Exposure	All thyroid disease^a
Exposure	Total^b	$n$ (%)^c	aOR (95% CI)
PBB-153^d
PBB-153 ln-transformed ( $Δ IQR = 0.76 ng / mL$ )	297	21 (7.1%)	0.69 (0.33, 1.44)
PCB-118
PCB-118 ln-transformed ( $Δ IQR = 0.06 ng / mL$ )	291	21 (7.2%)	1.50 (0.89, 2.53)
PCB-138
PCB-138 ln-transformed ( $Δ IQR = 0.26 ng / mL$ )	298	22 (7.4%)	1.07 (0.52, 2.20)
PCB-153
PCB-153 ln-transformed ( $Δ IQR = 0.30 ng / mL$ )	298	22 (7.4%)	0.98 (0.44, 2.20)
PCB-180
PCB-180 ln-transformed ( $Δ IQR = 0.24 ng / mL$ )	298	22 (7.4%)	0.81 (0.36, 1.83)
$Σ PCB$ (di-ortho)^e
$\sum PCB$ ln-transformed ( $Δ IQR = 0.81 ng / mL$ )	298	22 (7.4%)	0.93 (0.41, 2.11)

Note: IQR, interquartile range. All models control for lipids, age, and smoking status. Estimates are reported for natural log–transformed continuous exposures only owing to small numbers of cases in men.

^{^a}

Includes those who specified physician-diagnosed thyroid disease ( $n = 21$ ) and those who had thyroid hormone concentrations outside clinically normal ranges ( $n = 1$ ); includes 3 hyperthyroid, 8 hypothyroid, 1 other type and 10 type not specified.

^{^b}

PBB-153 analyses excludes 1 man who was diagnosed with hypothyroidism before the contamination event; PCB-118 analyses exclude 10 men that had missing values owing to unstable retention time on laboratory instrument, $Σ PCB$ (di-ortho) analyses include all observations.

^{^c}

11 men participated multiple times, so cell counts may not sum to total.

^{^d}

PBB-153 concentrations below the LOD were imputed using a distribution-based multiple imputation approach.

^{^e}

$PCB - 138 + PCB - 153 + PCB - 180$ .