Table 2.

Cytokine/chemokine levels on a LUMINEX assay in pancreatic lysates of F1 and F2 adult male offspring.

Cytokine/Chemokine	Inflammatory action	Produced by	Target cell/action	F1 Offspring					F2 Offspring
				Control ($\text{pg}/\mathrm{\mu }\mathrm{g}$)	LowerB ($\text{pg}/\mathrm{\mu }\mathrm{g}$)	UpperB ($\text{pg}/\mathrm{\mu }\mathrm{g}$)	LowerB (p-value)	UpperB (p-value)	Control ($\text{pg}/\mathrm{\mu }\mathrm{g}$)	LowerB ($\text{pg}/\mathrm{\mu }\mathrm{g}$)	UpperB ($\text{pg}/\mathrm{\mu }\mathrm{g}$)	LowerB (p-value)	UpperB (p-value)
IL4	pro/anti	Macrophages, eosinophills, basophills	Macrophages, T cells, ${\mathrm{T}}_{\mathrm{h}}0\to {\mathrm{T}}_{\mathrm{h}}2$	$3\mathrm{E}-4\pm 6\mathrm{E}-5$	$2\mathrm{E}-4\pm 7\mathrm{E}-5$	$3\mathrm{E}-4\pm 7\mathrm{E}-5$	0.60	0.75	$3\mathrm{E}-5\pm 5\mathrm{E}-5$	$1\mathrm{E}-4\pm 5\mathrm{E}-5$	$2\mathrm{E}-4\pm 5\mathrm{E}-5$	0.23	0.04
IL5	pro/anti	${\mathrm{T}}_{\mathrm{h}}2$ cells, mast Cells	B-cell growth, $\uparrow$ eosinophills	$4\mathrm{E}-4\pm 3\mathrm{E}-5$	$3\mathrm{E}-4\pm 3\mathrm{E}-5$	$7\mathrm{E}-4\pm 4\mathrm{E}-5$	0.08	0.01	$2\mathrm{E}-4\pm 4\mathrm{E}-4$	$4\mathrm{E}-4\pm 4\mathrm{E}-4$	$13\mathrm{E}-4\pm 4\mathrm{E}-4$	0.43	0.09
IL6	pro/anti	T-cells, macrophages	$\uparrow$ B-cells, naïve T cells $\to$${\mathrm{T}}_{\mathrm{h}}17$,$\downarrow {\mathrm{T}}_{\text{reg}}$	$6\mathrm{E}-4\pm 5\mathrm{E}-4$	$7\mathrm{E}-4\pm 5\mathrm{E}-4$	$22\mathrm{E}-4\pm 5\mathrm{E}-4$	0.89	0.08	$3\mathrm{E}-4\pm 6\mathrm{E}-4$	$12\mathrm{E}-4\pm 6\mathrm{E}-4$	$19\mathrm{E}-4\pm 5\mathrm{E}-4$	0.15	0.04
IL17	pro	${\mathrm{T}}_{\mathrm{h}}$ cells	Recruits macrophages and neutrophils	$2\mathrm{E}-4\pm 7\mathrm{E}-5$	$4\mathrm{E}-4\pm 8\mathrm{E}-5$	$4\mathrm{E}-4\pm 8\mathrm{E}-5$	0.20	0.33	$1\mathrm{E}-4\pm 9\mathrm{E}-5$	$2\mathrm{E}-4\pm 9\mathrm{E}-5$	$4\mathrm{E}-4\pm 8\mathrm{E}-5$	0.14	0.03
MCP1	pro	Chemoattractant produced by injured tissue, or infection	$\uparrow$ Macrophages, memory T cells, dendritic cells, basophils	$2\mathrm{E}-3\pm 4\mathrm{E}-4$	$3\mathrm{E}-3\pm 5\mathrm{E}-4$	$4\mathrm{E}-3\pm 5\mathrm{E}-4$	0.18	0.02	$2\mathrm{E}-3\pm 21\mathrm{E}-4$	$7\mathrm{E}-3\pm 21\mathrm{E}-4$	$8\mathrm{E}-3\pm 17\mathrm{E}-4$	0.27	0.09
$\text{TNF}\mathrm{\alpha }$	pro	Macrophages $\text{CD}{4}^{+}$, natural killer and mast cells	Macrophages, IL1- and IL6-producing cells	$4\mathrm{E}-4\pm 9\mathrm{E}-5$	$5\mathrm{E}-4\pm 1\mathrm{E}-4$	$5\mathrm{E}-4\pm 1\mathrm{E}-4$	0.59	0.53	$2\mathrm{E}-4\pm 2\mathrm{E}-4$	$3\mathrm{E}-4\pm 2\mathrm{E}-4$	$4\mathrm{E}-4\pm 1\mathrm{E}-4$	0.62	0.28
$\text{IFN}\mathrm{\gamma }$	pro	Natural killer cells, natural killer T-cells, macrophages, $\text{CD}{4}^{+}$, ${\text{CD}8}^{+}$	Macrophages, $\uparrow$ MHCII	$2\mathrm{E}-3\pm 1\mathrm{E}-3$	$4\mathrm{E}-3\pm 1\mathrm{E}-3$	$4\mathrm{E}-3\pm 1\mathrm{E}-3$	0.45	0.59	$2\mathrm{E}-3\pm 6\mathrm{E}-3$	$2\mathrm{E}-3\pm 6\mathrm{E}-3$	$9\mathrm{E}-3\pm 5\mathrm{E}-3$	0.99	0.85

Note: Data are normalized to total protein concentration as pg of cytokine or chemokine per $\mathrm{\mu }\mathrm{g}$ of total protein, and presented as $\text{mean}+\text{SEM}$. Decimal places are represented by E notation, where E represents base 10, followed by the power of 10 (example, $\mathrm{E}-3={10}^{-3}$, $\mathrm{E}-4={10}^{-4}$, $\mathrm{E}-5={10}^{-5}$). Information in columns 2, 3, and 4 is derived from Cavaillon 2001; Commins et al. 2010; Kimura and Kishimoto 2010; Kourilsky and Truffa-Bachi 2001; Turner et al. 2014. Control, 7% corn oil diet; LowerB, Lower BPA ($10\mathrm{\mu }\mathrm{g}/\mathrm{kg}/\mathrm{d}$); UpperB, Upper BPA ($10\mathrm{mg}/\mathrm{kg}/\mathrm{d}$). $n=3$ to $4\text{litters}$ per group. p-Values are from Dunnett’s test performed on log-transformed data, where required (F1 IL5, IL6, MCP1, and $\text{IFN}\mathrm{\gamma }$; F2 IL4, IL5 IL6, IL17, $\text{TNF}\mathrm{\alpha }$, and $\text{IFN}\mathrm{\gamma }$).