Table 2.
Cytokine/Chemokine | Inflammatory action | Produced by | Target cell/action | F1 Offspring | F2 Offspring | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Control () | LowerB () | UpperB () | LowerB (p-value) | UpperB (p-value) | Control () | LowerB () | UpperB () | LowerB (p-value) | UpperB (p-value) | ||||
IL4 | pro/anti | Macrophages, eosinophills, basophills | Macrophages, T cells, | 0.60 | 0.75 | 0.23 | 0.04 | ||||||
IL5 | pro/anti | cells, mast Cells | B-cell growth, eosinophills | 0.08 | 0.01 | 0.43 | 0.09 | ||||||
IL6 | pro/anti | T-cells, macrophages | B-cells, naïve T cells , | 0.89 | 0.08 | 0.15 | 0.04 | ||||||
IL17 | pro | cells | Recruits macrophages and neutrophils | 0.20 | 0.33 | 0.14 | 0.03 | ||||||
MCP1 | pro | Chemoattractant produced by injured tissue, or infection | Macrophages, memory T cells, dendritic cells, basophils | 0.18 | 0.02 | 0.27 | 0.09 | ||||||
pro | Macrophages , natural killer and mast cells | Macrophages, IL1- and IL6-producing cells | 0.59 | 0.53 | 0.62 | 0.28 | |||||||
pro | Natural killer cells, natural killer T-cells, macrophages, , | Macrophages, MHCII | 0.45 | 0.59 | 0.99 | 0.85 |
Note: Data are normalized to total protein concentration as pg of cytokine or chemokine per of total protein, and presented as . Decimal places are represented by E notation, where E represents base 10, followed by the power of 10 (example, , , ). Information in columns 2, 3, and 4 is derived from Cavaillon 2001; Commins et al. 2010; Kimura and Kishimoto 2010; Kourilsky and Truffa-Bachi 2001; Turner et al. 2014. Control, 7% corn oil diet; LowerB, Lower BPA (); UpperB, Upper BPA (). to per group. p-Values are from Dunnett’s test performed on log-transformed data, where required (F1 IL5, IL6, MCP1, and ; F2 IL4, IL5 IL6, IL17, , and ).