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. 2018 Apr 24;13(4):e0196404. doi: 10.1371/journal.pone.0196404

Fig 2. Kynurenine in the KAT-II active site.

Fig 2

The amino acids within 5.0 Å of kynurenine (green) were chosen for display, with PLP in magenta and residue Tyr-142 removed for clarity. Depicted is the aromatic ring forming pi-pi interactions (green dashes) with Tyr-74 and pi-cation interactions (blue dashes) with Arg-20. A hydrogen bond (yellow dashes) between the amine group and Asn-202, and a salt bridge (yellow dashes) formed between the carboxyl and Arg-399 helps anchor kynurenine in the correct conformation for transamination. Image generated with PyMOL [29].