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The amino acids within 5.0 Å of JN-01 (green) were chosen for display. Residues Ser-143, Gly-144, and Gln-289 were removed for clarity. The oxygen atoms in the sulfonamide form hydrogen bonds (yellow dashes) with Asn-202 and Lys-263, and the aromatic ring has pi-pi interactions (green dashes) with Tyr-74. Image generated with PyMOL [29].
