Table 2.
List of isoprenoid modifications on a-factor reported in the literature
Entry | Isoprenoid group (RI) YIIKGVFWDPAC(RI)-OCH3 | Wild-type activity (%) |
---|---|---|
9 | H | 0.1 |
10 | Methyl | 0.2 |
11 | Hexadecanyl | 1.5 |
12 | Benzyl | 1.5 |
13 | Prenyl | 12.0 |
14 | Geranyl | 3.0 |
15 | Geranylgeranyl | 25.0 |
16 | (CH2)4-CH3 | 5.2 |
17 | (CH2)5-NBD | 1.3 |
18 | (CH2)9-CH3 | 150.0 |
19 | (CH2)10-NBD | 15.0 |
20 | 3-ethylfarnesyl | 200 |
21 | 3-vinylfarnesyl | 800 |
22 | 3-t-butylfarnesyl | 200 |
23 | 3-phenylfarnesyl | 200 |
24 | C5-benzophenone | 48.0 |
25 | C10-benzophenone | 24.0 |
26 | C10-alkyne | 800 |
27 | C15-alkyne | 200 |
28 | C15-azide | 100 |
29 | C15-dihydro-azide | 100 |