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. Author manuscript; available in PMC: 2018 Apr 24.
Published in final edited form as: Curr Top Pept Protein Res. 2017;18:133–151.

Table 2.

List of isoprenoid modifications on a-factor reported in the literature

Entry Isoprenoid group (RI) YIIKGVFWDPAC(RI)-OCH3 Wild-type activity (%)
9 H 0.1
10 Methyl 0.2
11 Hexadecanyl 1.5
12 Benzyl 1.5
13 Prenyl 12.0
14 Geranyl 3.0
15 Geranylgeranyl 25.0
16 (CH2)4-CH3 5.2
17 (CH2)5-NBD 1.3
18 (CH2)9-CH3 150.0
19 (CH2)10-NBD 15.0
20 3-ethylfarnesyl 200
21 3-vinylfarnesyl 800
22 3-t-butylfarnesyl 200
23 3-phenylfarnesyl 200
24 C5-benzophenone 48.0
25 C10-benzophenone 24.0
26 C10-alkyne 800
27 C15-alkyne 200
28 C15-azide 100
29 C15-dihydro-azide 100