TABLE 5.
Summary of VP shunt ventricular catheters included in statistical analysis
| Catheter No. | Patient No. | Patient Age (mos) | Patient Sex | Hydrocephalus Etiology | Time Catheter Implanted (days) | Catheter Make | Primary Cellular Response | Notes |
|---|---|---|---|---|---|---|---|---|
| 1 | 1 | 0.33 | M | Myelo | 7 | Med A | Microglia | |
| 2 | 2 | 44 | M | IVH | 13 | Med A | Microglia | |
| 3 | 3 | 5 | F | IVH | 40 | Med A | Microglia | |
| 4 | 4 | 6 | M | IVH | 46 | Med A | Microglia | |
| 5 | 5 | 1 | M | AS | 23 | Med A | Microglia | Microglia response example in Fig. 4 |
| 6 | 6 | 20 | F | Tumor | 41 | Cod B H | Microglia | |
| 7 | 7 | 122 | M | AC (quadrigeminal) | 3 | Med A | Microglia | |
| 8* | 8* | 151 | F | DWV | 4 | Cod B H | Mixed | |
| 9* | 8* | 151 | F | DWV | 4 | Cod B H | Mixed | |
| 10 | 2 | 33 | M | IVH | 130 | Med A | Mixed | |
| 11 | 9 | 10 | F | DW | 128 | Med A | Mixed | |
| 12 | 10 | 234 | M | IVH | 62 | Med A | Mixed | |
| 13 | 11 | 206 | F | AS | 13 | Med A | Mixed | Secondary attachment of sparse cells w/punctate TTR+ labeling via astrocytes in 5/16 holes imaged |
| 14 | 12 | 109 | F | IVH (loculated) | 64 | Med A | Mixed | Secondary attachment of TTR+ cells via astrocytes in 3/16 holes imaged |
| 15 | 12 | 110 | F | IVH (loculated) | 28 | Med A | Mixed | |
| 16 | 12 | 110 | F | IVH (loculated) | 1 | Med A | Mixed | |
| 17 | 13 | 4 | M | IVH | 12 | Med A | Mixed | Mixed response example in Fig. 4 |
| 18 | 14 | 2.5 | M | Myelo | 73 | Med A | Mixed | Extensive secondary attachment of choroid plexus (Fig. 6) |
| 19 | 9 | 6 | F | DW | 59 | Med A | Astrocyte | Example in Fig. 2; secondary attachment of TTR+ cells in 1/16 holes imaged |
| 20 | 15 | 153 | F | Myelo | 8 | Cod B H | Astrocyte | |
| 21 | 16 | 9 | M | IVH | 215 | Med A | Astrocyte | Secondary attachment of TTR+ cells in 3/16 holes imaged (Fig. 5) |
| 22 | 17 | 244 | F | Myelo | 3873 | Cod AF | Astrocyte | Secondary attachment of TTR+ cells in 1/20 holes imaged |
| 23 | 12 | 110 | F | IVH (loculated) | 2312 | Med S | Astrocyte | Astrocyte response example in Fig. 4; sparse secondary attachment of TTR+ cells in 1/16 holes imaged |
| 24 | 18 | 33 | M | AC (suprasellar) | 632 | Cod B M | Astrocyte |
AC = arachnoid cyst; AS = aqueductal stenosis; Cod AF = Codman Accu-Flo; Cod B H = Codman Bactiseal Holter; Cod B M = Codman Bactiseal Medos; DW = Dandy-Walker; DWV = Dandy-Walker variant; IVH = intraventricular hemorrhage of prematurity; Med A = Medtronic Ares; Med S = Medtronic barium-impregnated ventricular catheter; Myelo = myelomeningocele; TTR+ = TTR positive.
*
The 2 catheters received from Patient 8 were implanted and explanted at the same time and demonstrated nearly identical mixed cellular responses and, as such, were tabulated only once for the purposes of statistical analysis.