Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Definition of resistance and intolerance to hydroxyurea in essential thrombocythemia73
| 1. Platelets >600 × 109/L after 3 months of ≥2 g/day of HU (≥2.5 g/day if body weight >80 kg) |
| 2. Platelets <400 × 109/L and leukocytes <2.5 × 109/L at any dose of HU |
| 3. Platelets <400 × 109/L and hemoglobin <10 g/dL at any dose of HU |
| 4. Presence of leg ulcers or other unacceptable muco-cutaneous manifestations at any dose of HU |
| 5. HU-related fever |
