Table 1.
Differentially Expressed Proteins between CMTCs and HMTCsa
| accession | protein name | abbreviation | p value | log2(CMTCs/HMTCs) |
|---|---|---|---|---|
| Down-regulated | ||||
| P07237 | protein disulfide-isomerase | P4HB | 0.006176 | −5.46123 |
| P31939 | bifunctional purine biosynthesis protein PURH | ATIC | 0.000673 | −5.39358 |
| P10599 | thioredoxin | TXN | 0.001671 | −3.81445 |
| Q9UQ80 | proliferation-associated protein 2G4 | PA2G4 | 0.00191 | −3.78786 |
| Q00839 | heterogeneous nuclear ribonucleoprotein U | HNRNPU | 0.000424 | −3.78086 |
| Q16881 | thioredoxin reductase 1, cytoplasmic | TXNRD1 | 0.002643 | −3.44095 |
| O95994 | anterior gradient protein 2 homologue | AGR2 | 0.000738 | −3.06049 |
| P17987 | T-complex protein 1 subunit alpha | TCP1 | 0.003758 | −2.98979 |
| P49411 | elongation factor Tu, mitochondrial | TUFM | 9.83 × 10−5 | −2.96518 |
| P51571 | translocon-associated protein subunit delta | SSR4 | 0.000953 | −2.95912 |
| P42704 | leucine-rich PPR motif-containing protein, mitochondrial | LRPPRC | 0.000225 | −2.45097 |
| Q16629 | serine/arginine-rich splicing factor 7 | SRSF7 | 1.39 × 10−6 | −2.39883 |
| Q14112 | nidogen-2 | NID2 | 0.000129 | −2.25182 |
| P05187 | alkaline phosphatase, placental type | ALPP | 0.004714 | −2.17463 |
| Q9Y224 | UPF0568 protein C14orf166 | C14orf166 | 0.008743 | −1.83512 |
| Q8IVM0 | coiled-coil domain-containing protein 50 | CCDC50 | 0.005208 | −1.70429 |
| P04114 | apolipoprotein B-100 | APOB | 0.002248 | −1.47771 |
| P61158 | actin-related protein 3 | ACTR3 | 0.007959 | −1.47413 |
| O95202 | LETM1 and EF-hand domain-containing protein 1, mitochondrial | LETM1 | 0.004901 | −1.30823 |
| Q8N715 | coiled-coil domain-containing protein 185 | CCDC185 | 0.009593 | −1.30689 |
| Q9UMZ3 | phosphatidylinositol phosphatase PTPRQ | PTPRQ | 0.006533 | −1.27531 |
| Q8N9N8 | probable RNA-binding protein EIF1AD | EIF1AD | 0.00411 | −1.1958 |
| Q96FQ6 | protein S100-A16 | S100A16 | 0.003489 | −1.11726 |
| Q96I13 | abhydrolase domain-containing protein 8 | ABHD8 | 0.001347 | −1.1119 |
| P05204 | nonhistone chromosomal protein HMG-17 | HMGN2 | 0.000283 | −1.07958 |
| P20340 | Ras-related protein Rab-6A | RAB6A | 0.007328 | −1.0464 |
| P04637 | cellular tumor antigen p53 | TP53 | 9.45 × 10−6 | −1.02266 |
| Up-Regulated | ||||
| P20042 | eukaryotic translation initiation factor 2 subunit 2 | EIF2S2 | 0.003331 | 1.062531 |
| Q13838 | spliceosome RNA helicase DDX39B | DDX39B | 0.00506 | 1.08455 |
| P11586 | C-1-tetrahydrofolate synthase, cytoplasmic | MTHFD1 | 1.64 × 10−5 | 1.101048 |
| P17844 | probable ATP-dependent RNA helicase DDX5 | DDX5 | 0.009201 | 1.10227 |
| Q9UHD1 | cysteine and histidine-rich domain-containing protein 1 | CHORDC1 | 0.001193 | 1.110927 |
| P23526 | adenosylhomocysteinase | AHCY | 0.000506 | 1.1153 |
| P43243 | matrin-3 | MATR3 | 4.21 × 10−5 | 1.119641 |
| P16070 | CD44 antigen | CD44 | 0.000256 | 1.130534 |
| P55084 | trifunctional enzyme subunit beta, mitochondrial | HADHB | 0.000465 | 1.147197 |
| P30044 | peroxiredoxin-5, mitochondrial | PRDX5 | 0.004756 | 1.164929 |
| Q14247 | Src substrate cortactin | CTTN | 0.005807 | 1.177613 |
| P17812 | CTP synthase 1 | CTPS1 | 0.000178 | 1.388005 |
| Q9H0H5 | Rac GTPase-activating protein 1 | RACGAP1 | 0.000123 | 1.522765 |
| O76003 | glutaredoxin-3 | GLRX3 | 3.17 × 10−6 | 1.661114 |
| Q15691 | microtubule-associated protein RP/EB family member 1 | MAPRE1 | 0.003605 | 1.70147 |
| Q14204 | cytoplasmic dynein 1 heavy chain 1 | DYNC1H1 | 0.003087 | 1.701699 |
| Q1KMD3 | heterogeneous nuclear ribonucleoprotein U-like protein 2 | HNRNPUL2 | 0.000377 | 1.712421 |
| P50454 | serpin H1 | SERPINH1 | 0.000736 | 1.726279 |
| O00410 | importin-5 | IPO5 | 0.007701 | 2.071047 |
| P62158 | calmodulin | CALM1 | 0.004363 | 2.12305 |
| P30153 | serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | PPP2R1A | 7.52 × 10−5 | 2.129178 |
| Q16891 | mitochondrial inner membrane protein | IMMT | 0.002204 | 2.174018 |
| Q04917 | 14–3–3 protein eta | YWHAH | 0.000902 | 2.192749 |
| Q9UBQ7 | glyoxylate reductase/hydroxypyruvate reductase | GRHPR | 0.003872 | 2.199724 |
| P14868 | aspartate–tRNA ligase, cytoplasmic | DARS | 0.00541 | 2.218161 |
| Q6PIU2 | neutral cholesterol ester hydrolase 1 | NCEH1 | 0.008315 | 2.237665 |
| Q01082 | spectrin beta chain, nonerythrocytic 1 | SPTBN1 | 0.001524 | 2.244113 |
| P31946 | 14–3–3 protein beta/alpha | YWHAB | 0.001868 | 2.411062 |
| P31947 | 14–3–3 protein sigma | SFN | 2.44 × 10−7 | 2.485867 |
| P60660 | myosin light polypeptide 6 | MYL6 | 0.003148 | 2.707021 |
| P13667 | protein disulfide-isomerase A4 | PDIA4 | 0.006502 | 2.844721 |
| Q9Y618 | nuclear receptor corepressor 2 | NCOR2 | 0.002516 | 2.887301 |
| P34932 | heat shock 70 kDa protein 4 | HSPA4 | 0.007072 | 3.339028 |
| P13797 | plastin-3 | PLS3 | 0.000567 | 3.353014 |
| P52272 | heterogeneous nuclear ribonucleoprotein M | HNRNPM | 0.005324 | 3.824637 |
a
Compared with HMTCs, 35 proteins were up-regulated with 27 down-regulated in CMTCs.