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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2017 Nov 22;338:112–123. doi: 10.1016/j.taap.2017.11.014

Figure 1. Effects of PPARα activation and deficiency on liver weight, hepatic free cholesterol, and bile flow.

Figure 1

PPARα activation was achieved by a four-day treatment of CLOF (300 mg/kg, i.p.). The other groups of mice were administered with vehicle control (corn oil, i.p.). Bile was collected for 40 minutes from age-matched WT and PPARα-null female mice (n>5 per treatment group) for 40 minutes. Liver weight (LW) is expressed as a percent of bodyweight (BW). Hepatic free cholesterol was assayed by using a WAKO free cholesterol kit. Bile flow rates were normalized to liver weight (LW) and body weight (BW), respectively. Data represent means ± S.E.M. *p<0.05 versus vehicle treatment group; #p<0.05 versus WT group.