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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2017 Nov 22;338:112–123. doi: 10.1016/j.taap.2017.11.014

Figure 8. Effects of PPARα activation and deficiency on mRNA expression of BA-synthetic enzymes and transporters in the liver.

Figure 8

(A) Heat map of genes involved in BA synthesis and transport in the liver. The colors on the heatmap corresponded to the relative changes in average gene expression. Red represents up-regulation while green represents down-regulation. (2) QuantiGene Plex 2.0 Assay was performed to measure the gene expression of BA-synthetic enzymes (Cyp7a1, Cyp8b1, Cyp27a1, Cyp7b1, Bal, and Baat) and BA transporters (Ntcp, Oatp1a1, Oatp1b2, Mrp3, Mrp2 and Bsep). Relative mRNA levels were calculated with vehicle controls set as 100%. Data represent means ± S.E.M. *p<0.05 versus vehicle treatment group; #p<0.05 versus WT group.