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. Author manuscript; available in PMC: 2018 Jun 20.
Published in final edited form as: Sci Signal. 2018 Mar 20;11(522):eaao1591. doi: 10.1126/scisignal.aao1591

Table 1. Ependymal cilia defects are proportionate to the catalytic activities of various mutant forms of SHP2.

Brain sections prepared from 12-month-old mice (n=3 mice per genotype) were immunofluorescently stained for acetyl α-tubulin to mark cilia, and the ependymal cilia on the walls of ventricles were examined.

Mice Catalytic activity of mutant SHP2 Ependymal cilia
Ptpn11E76K/+/Nestin-Cre+ Substantially enhanced Severely abnormal
Ptpn11D61G/+ (NS mice) Enhanced Abnormal in some areas *
Ptpn11Y279C/+ (NSML mice) No catalytic activity Normal
*

Ependymal cilia of the third ventricle, but not the lateral ventricles, were abnormal.