. Author manuscript; available in PMC: 2018 Jun 20.

Published in final edited form as: Sci Signal. 2018 Mar 20;11(522):eaao1591. doi: 10.1126/scisignal.aao1591

Table 2. The increased catalytic activity of SHP2^E76K is required for its detrimental effect on ependymal cell development.

Ptpn11^E76K,C459S/+ double mutation knock-in and Ptpn11^E76K/+ single mutation knock-in mice were monitored for 15 months. The incidences of frank hydrocephalus in the euthanized animals were documented.

Mice ^*	Incidence of frank hydrocephalus
Ptpn11^E76K/+/Nestin-Cre⁺	26/56
Ptpn11^+/+/Nestin-Cre⁺	0/58
Ptpn11^{E76K C459S/+}	0/56
Ptpn11^+/+	0/44

Mice were monitored for 15 months.

Table 2. The increased catalytic activity of SHP2E76K is required for its detrimental effect on ependymal cell development.

Table 2. The increased catalytic activity of SHP2^E76K is required for its detrimental effect on ependymal cell development.