Table 3.

Dose-response models for secondary cancers in the head and neck region based on cohort studies of long-term cancer survivors. Relevance scores presented as total and (patient material, study design, radiation therapy, modeling approach).

Secondary cancer
Endpoint definition	Patient material	Time point	Significant non-dosimetric risk factors	Model and parameters (95% CIs)	Reference
Treatment-related esophageal cancer in a cohort of breast cancer survivors	Nested case-control study of 289,748 breast cancer survivors with 252 cases and 488 matched controls	Between 5 and 37 years post breast cancer treatment	Smoking: (Current vs. Nonsmoker) Hormonal therapy in last 5 years: (Yes vs. No)	Linear model: EOR/Gy Esophagus mean dose = 0.09 (0.04, 0.16) ORSmoking = 2.4 (1.1, 5.7) ORHormonal therapy = 0.4 (0.2, 0.8) Performance measures N/A	Morton et al. 201265 Relevance score: 110 (40, 20, 5, 45)
Radiation-induced secondary cancer of the mouth and pharynx	Cohort study based on atomic bomb survivors receiving high doses and Hodgkin’s lymphoma patients treated with RT	Time factors included in model	Age at exposure: (Continuous) Attained age: (Continuous)	EAR plateau OED model: αMouth and pharynx = 0.045 βEAR = 0.73 (0.30, 1.60) γage at exposure = −0.024 γattained age = 2.38 Performance measures N/A	Schneider et al. 201167 Relevance score: 85 (40, 10, 5, 30)