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. Author manuscript; available in PMC: 2018 Apr 24.
Published in final edited form as: Curr Opin Struct Biol. 2014 Jun 19;26:92–103. doi: 10.1016/j.sbi.2014.05.008

Figure 1. Spectrum of structural divergence which preserves biochemical function.

Figure 1

The spectrum is broken up into distinct classes of structural divergence separated by dotted lines. Example structures are depicted as topology diagrams with arrows representing β-strands and coils representing α-helices. ‘B’ represents the ‘baseline’ class of structural divergence. Class 1: representatives of papain-like peptidases; Class 2: restriction endonuclease fold with modified part of the secondary structural elements colored in yellow; Class 3: BECR fold members with divergent active site residues highlighted in green; Class 4: transition between NFACT and Fpg-MutM-EndoVIII DNA glycosylase proteins are accompanied by linear arrays of secondary structural elements to show rewiring, each duplicated basic 4-stranded element is given a distinct color; Class 5: topological transmogrification observed in the obligate dimer-forming BcbF family of HAD domains, strands are labeled, and monomers are given distinct colors.