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. 2018 Apr 24;9:1622. doi: 10.1038/s41467-018-03854-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — SHARP1 binds to actively transcribed genes and positively regulates target genes. a Integrated view of SHARP1 binding sites in conjunction with H3K4me3, H3K27ac, and H3K27me3 profiles across promoters, introns and intergenic regions. Top enriched motifs within SHARP1 ChIP-seq peaks in ML-2 cells are shown according to their genomic location discovered by peak-motifs module from the RSAT suite, using oligomer length ranging from 6 to 8 nucleotides and the 'merge lengths for assembly' option. b Box plot showing the expression levels in microarray analysis of ML-2 cells for the all genes (25293 genes) and genes enriched with SHARP1 + H3K4me3 (6459 genes), SHARP1 + H3K27ac (5840 genes), and SHARP1 + H3K27me3 (1055 genes) identified in ChIP-seq analysis. The box extends from the 25^th to 75^th percentiles and the whisker extends from the minimum level to the maximum. Median value is plotted in the box. c Representative SHARP1 binding peaks in the known target gene loci (circadian clock genes and MLH1). d Pathway analysis for the genes in the SHARP1 and H3K4me3 co-bounded regions within the promoter and gene body