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. 2018 Apr 25;8:89. doi: 10.1038/s41398-018-0137-3

Fig. 1. THC treatment regulates genes involved in mitochondrial and glutamate pathways.

Fig. 1

a RNA sequencing of hiPSC-derived neurons reveals 497 genes (acute) and 810 genes (chronic) are significantly changed following THC exposure, including. b genes involved in mitochondrial (e.g., COX7A2, MT-CO1, and MT-CO3) and glutamate (e.g., GRID2) pathways (Quantitative RT–PCR (qRT–PCR); Ordinary one-way ANOVA with Tukey’s multiple comparisons test: *p < 0.05. n = 5 (see qRT–PCR, Ca–Ce, Supplementary Table S1)). Ingenuity pathway analysis shows that mitochondrial oxidative phosphorylation is strongly altered after both acute c and chronic d THC exposure