Fig. 3.

Therapeutic administration of the SMZAb cocktail to ZIKV-infected pregnant Indian-origin rhesus macaques blocks maternal viremia but does not prevent transmission of virus to fetus. a Treatment study design. Four pregnant rhesus macaques were challenged with 10,000 PFU of ZIKV Rio U-1/2016. On day 3 post challenge, we administered a cocktail containing the three nmAbs, SMZAbs 1, 2, and 5 at a dose of 20 mg kg⁻¹ each to three rhesus macaques (Group 1). An untreated animal was used as a control (Group 2). Four macaques infected in the third semester of pregnancy (M8–M11) were used as historical controls. b Serum and AF were collected at the indicated time points for viral load and IgG measurements. c Serum viral loads for SMZAb-treated (open symbols) and control (solid square) macaques