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. 2018 Apr 18;9:801. doi: 10.3389/fimmu.2018.00801

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Copyright © 2018 Li, Yang, Li, Zhu, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of Dscam-regulated pathogen-specific phagocytosis. (A) Lower concentrations of membrane-bound and soluble EsDscam in normal hemocytes and cell-free hemolymph. (B) The expression of membrane-bound and soluble EsDscam (including bacteria-specific induced and non-specific induced EsDscam isoforms) is highly induced after bacterial infection. (C) Bacteria-specific induced soluble EsDscam isoforms bind with high affinity to the original bacteria, while the other soluble isoforms show weak or no binding with the bacteria. (D) Bacteria-specific binding soluble EsDscam isoforms interact with the membrane-bound EsDscam containing the same extracellular region. (E) EsDscam regulates pathogen-specific phagocytosis in crab hemocyte.