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. 2018 Apr 24;8:6483. doi: 10.1038/s41598-018-24762-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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B cell responses and total IgG secretion following immunization with quadrivalent vaccines. BALB/c mice (n = 5/group) were immunized subcutaneously at the base of the tail with PBS alone (control) or 80 μg of quadrivalent VLP. Splenocytes were harvested on day 21 and frequencies of total HCV specific antibody secreting cells (ASCs) in each group (PBS, or vaccine combined with Alum, CFA or Montanide) (A) and total IgG (B) were determined by B cell ELISpot assay. The y-axis shows the antibody secreting cell (ASC) number/million splenocytes. Individual animals are presented for each group, with the mean value being represented by the horizontal bar.