Table 3.

Genotype analysis of 7 SNPs

SNP	Genetic model	Group	Genotype distribution	χ2	P	OR (95% CI)
rs6701216	Genotype	Patient	107/139/59
	CC/CT/TT	Control	179/168/36
	Dominant	Patient	198/107	9.494	0.002	1.624(1.192–2.212)
	(TT + CT/CC)	Control	204/179
	Recessive	Patient	59/246	14.109	0.000	2.312(1.481–3.609)
	(TT/CT + CC)	Control	36/347
rs4112788	Genotype	Patient	98/119/88
	(CC/CT/TT)	Control	148/174/61
	Dominant	Patient	207/98	3.134	0.077	1.330 (0.970–1.825)
	(TT + CT/CC)	Control	235/148
	Recessive	Patient	88/217	16.719	0.000	2.141(1.480–3.096)
	(TT/CT + CC)	Control	61/322
rs12023196	Genotype	Patient	79/124/102
	(CC/CT/TT)	Control	42/171/170
	Dominant	Patient	203/102	8.507	0.004	1.588(1.163–2.170)
	(CC + CT/TT)	Control	213/170
	Recessive	Patient	79/226	26.131	0.000	2.838(1.883–4.278)
	(CC/CT + TT)	Control	42/341
rs512208	Genotype	Patient	104/126/75
	(GG/GT/TT)	Control	193/160/30
	Dominant	Patient	201/104	18.373	0.000	1.963(1.440–2.677)
	(TT + GT/GG)	Control	190/193
	Recessive	Patient	75/230	36.867	0.000	3.837(2.435–6.047)
	(TT/GT + GG)	Control	30/353
rs4845454	Genotype	Patient	100/127/78
	(TT/CT/CC)	Control	129/194/60
	Dominant	Patient	205/100	0.061	0.805	1.041(0.756–1.433)
	(CC + CT/TT)	Control	254/129
	Recessive	Patient	78/227	10.395	0.001	1.850 (1.269–2.697)
	(CC/CT + TT)	Control	60/323
rs4085613	Genotype	Patient	98/120/87
	(CC/AC/AA)	Control	124/189/70
	Dominant	Patient	207/98	0.005	0.946	1.011(0.733–1.395)
	(AA + AC/CC)	Control	259/124
	Recessive	Patient	87/218	10.124	0.001	1.784(1.246–2.555)
	(AA/AC + CC)	Control	70/313
rs1886734	Genotype	Patient	79/127/99
	(TT/GT/GG)	Control	63/194/126
	Dominant	Patient	206/99	0.015	0.903	1.020(0.740–1.406)
	(TT + GT/GG)	Control	257/126
	Recessive	Patient	79/226	9.262	0.002	1.776(1.224–2.576)
	(TT/GT + GG)	Control	63/320

OR odds ratio, CI confidence interval, P asymptotic p value for the epistatic effect between the patient and control