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Proposed model of negative regulation of autophagy by NALP3 imflammasome. Autophagy acts to downregulate NLRP3 inflammasome activation and subsequent caspase-1 cleavage and IL-1β release in PrP106-126-treated microglia, while the NLPR3 inflammasome limits autophagy cleaving TRIF via activated caspase-1.
