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. 2018 Apr 18;9:586. doi: 10.3389/fmicb.2018.00586

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Copyright © 2018 Rauf, Zubair, Ateeq, Dabeer, Pachauri, Ajmal and Owais.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of ZnO-NR-DAS combination on MRSA induced skin infection in Balb/C mice (A) Efficacy of ZnO-NR-DAS combination against MRSA induced skin infection. (B) Mice were infected topically with MRSA ATCC BAA 1708. The infected mice were treated with ZnO-NR and DAS based formulations. Mice inoculated with PBS alone were used as a healthy control. On day 10 post treatment, small pieces corresponding to skin lesions were cut, homogenized and bacterial count was determined employing CFU assay. (C) On day 10, biopsy specimens were fixed in 4% neutral buffered formalin and embedded in parafilm. The specimens were stained with hematoxylin and eosin to perform histopathological study.