Table 2.
EBOV miRNAs were detected in cynomolgus macaques intramuscularly injected with EBOV/Makona.
| EBOV miRNA | miRNA concentration by day post-exposure (fM) | ||||
|---|---|---|---|---|---|
| Day −1 (EBOV load ND) | Day 3 (ND) | Day 6 (10.01 pM) | Day 9 (1.35 pM) | Day 10 (4.19 pM) | |
| miR-1-3p | ND | ND | 9.95 ± 15.74 | 2.74 ± 2.79 | 35.69 ± 31.42 |
| miR-1-5p | ND | 0.37 ± 0.64 | 250.82 ± 22.56 | 203.89 ± 15.91 | 328.52 ± 34.95 |
| miR-2-3p | ND | ND | 2.11 ± 1.40 | 1.40 ± 0.913 | 6.96 ± 7.69 |
| miR-T1-3p | ND | ND | 1.60 ± 0.39 | 4.47 ± 0.50 | 5.81 ± 0.85 |
| miR-T1-5p | ND | ND | 4.20 ± 1.23 | 1.96 ± 0.72 | 4.91 ± 1.52 |
| miR-T2-3p | ND | ND | 0.68 ± 0.30 | 1.17 ± 1.23 | 2.39 ± 0.92 |
| miR-T3-3p | ND | ND | 19.62 ± 10.17 | 50.21 ± 5.74 | 59.64 ± 10.12 |
| miR-T3/T4-5p | ND | ND | 10.56 ± 2.24 | 30.60 ± 7.27 | 36.44 ± 2.32 |
| miR-T4-3p | ND | ND | 12.06 ± 4.48 | 29.20 ± 5.80 | 38.83 ± 6.22 |
| miR-VP-3p | ND | ND | 0.02 ± 0.02 | 0.23 ± 0.40 | 0.24 ± 0.27 |
Note: Data are presented as the mean ± SD of biological replicates assayed in technical triplicate. Values in bold font indicate amplification in only one of three biological samples, with mean ± SD only for that sample. The corresponding EBOV load at each timepoint is given in parentheses below each day. ND = not detected.