Table 3.
EBOV miRNAs were detected in BALB/c mice intraperitoneally injected with mouse-adapted EBOV/Mayinga.
| EBOV miRNA | miRNA concentration by day post-exposure (fM) | |||||
|---|---|---|---|---|---|---|
| Day 0 (EBOV load ND) | Day 1 (4.17E-05 pM) | Day 2 (0.04 pM) | Day 3 (3.99 pM) | Day 4 (20.20 pM) | Day 7 (0.22 pM) | |
| miR-1-3p | ND | ND | ND | 8.82 ± 6.92 | 20.94 ± 14.68 | 51.32 ± 37.27 |
| miR-1-5p | ND | ND | 1.08 ± 0.99 | 8.52 ± 1.51 | 25.11 ± 2.55 | 129.37 ± 6.68 |
| miR-2-3p | ND | ND | ND | 2.40 ± 1.23 | 5.00 ± 1.11 | 12.41 ± 2.36 |
| miR-T1-3p | ND | ND | ND | 0.74 ± 0.16 | 1.78 ± 0.41 | 18.44 ± 1.83 |
| miR-T1-5p | ND | ND | ND | ND | 14.57 ± 8.14* | ND |
| miR-T2-3p | ND | ND | ND | ND | 2.49 ± 0.77 | 1.26 ± 0.92 |
| miR-T3-3p | ND | ND | 0.83 ± 0.82 | 3.45 ± 2.86 | 12.46 ± 6.77 | 101.75 ± 10.34 |
| miR-T3/T4-5p | ND | ND | 0.07 ± 0.12 | 2.32 ± 0.76 | 3.74 ± 0.92 | 46.81 ± 3.31 |
| miR-T4-3p | ND | ND | 1.19 ± 2.06 | 3.67 ± 1.16 | 6.25 ± 3.87 | 55.58 ± 7.26 |
| miR-VP-3p | ND | ND | ND | 0.05 ± 0.10 | 0.30 ± 0.46 | 0.62 ± 1.07 |
Note: Data are presented as the mean ± SD of biological replicates assayed in technical triplicate. Values in bold font indicate amplification in only one of three biological samples, with mean ± SD only for that sample. The corresponding EBOV load at each timepoint is given in parentheses below each day. ND = not detected. *Value given is based on the mismatched miR-T1-5p sequence.