Table 4.
EBOV miRNAs were present in human samples during infection with EBOV/Makona.
| EBOV miRNA | miRNA concentration by patient sample designator (fM) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| G1 (0.031 pM) |
G2 (0.367 pM) |
G3 (0.336 pM) |
G4 (0.012 pM) |
G5 (7.64 pM) |
G6 (7.50 pM) |
G8 (3.47E-05 pM) |
G9 (1.61E-04 pM) |
G14 (1.04E-04 pM) |
|
| miR-1-3p | 2.67 ± 4.62* | 21.74 ± 23.92 | 15.87 ± 10.68 | 21.78 ± 10.63 | |||||
| miR-1-5p | 0.48 ± 0.11 | 110.09 ± 1.86 | 4.17 ± 0.87 | 361.67 ± 48.69 | 217.95 ± 5.70 | 1.39 ± 0.95 | 0.21 ± 0.26 | ||
| miR-2-3p | 0.86 ± 0.74 | 1.38 ± 0.58 | 1.84 ± 0.25 | ||||||
| miR-T1-3p | 4.62 ± 1.02 | 0.38 ± 0.17 | 1.36 ± 0.45 | 9.42 ± 1.41 | 5.03 ± 2.31 | ||||
| miR-T1-5p | 0.58 ± 0.99 | 4.55 ± 1.39 | 6.47 ± 0.56 | ||||||
| miR-T2-3p | 0.83 ± 0.87 | 2.80 ± 0.67 | 2.48 ± 1.26 | ||||||
| miR-T3-3p | 9.89 ± 4.67 | 36.29 ± 8.78 | 14.15 ± 8.30 | 2.71 ± 4.70* | |||||
| miR-T3/T4-5p | 14.17 ± 1.46 | 0.34 ± 0.35 | 27.02 ± 4.75 | 9.73 ± 2.65 | 0.17 ± 0.24 | ||||
| miR-T4-3p | 8.52 ± 1.75 | 19.69 ± 5.15 | 5.02 ± 2.13 | ||||||
| miR-VP-3p | 0.28 ± 0.41 | 0.08 ± 0.14* | |||||||
Note: Data are presented as the mean ±SD of three technical replicates. Values in bold font indicate amplification in only one of three replicates. Blank cells indicate that the corresponding miRNA was not detected. The corresponding EBOV load for each individual is given in parentheses below the patient designator. Values in italicized font denote miRNA concentration higher than viral load.