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. 2018 Apr 24;9:1629. doi: 10.1038/s41467-018-04107-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — The mechanism of action in alpha particle-promoted feed-forward oncoaddiction. The interaction of α-particles with tumor tissue produces DNA damage. The ensuing transcriptional response prompts the hormone-DNA circuit to upregulate AR expression. KLK2 expression subsequently upregulates due to AR and produces more hk2 target epitope for [²²⁵Ac]hu11B6