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. 2018 Apr 24;8:6438. doi: 10.1038/s41598-018-24695-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Forced expression of Elf3 increases cartilage degradation following destabilization of the medial meniscus (DMM). (A) Representative images of Safranin O-stained histological sections from DMM-operated 6-month-old WT and Elf3Tg male mice at 8 weeks post-DMM. The arrows indicate sites of cartilage lesions. (B) OARSI histological scores showing increased cartilage degradation in DMM-operated Elf3-overexpressing mice (WT = 6; Elf3Tg = 5). Data are shown as median and C.I. *p < 0.05 by Mann-Whitney test.