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. 2018 Apr 24;8:6434. doi: 10.1038/s41598-018-24710-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fear conditioning and MWM tests in the four animal groups (WT, WT_M, Tg2576 and Tg2576_M). The results are expressed as the mean ± SEM (n = 10–12). Statistical significance was analysed by two-way ANOVA with Tukey’s post-hoc test. Panel a, percentage of freezing in the fear conditioning test performed in 4-month-old animals. Panels b-c, escape latency of 8-month-old mice in the visible (b) and hidden-platform (c) of the MWM. *p < 0.05, **p < 0.01 respect to WT; ^##p < 0.01 respect to Tg2576; ^$p < 0.05 day 1 respect to day 8.