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. 2018 Apr 24;8:6434. doi: 10.1038/s41598-018-24710-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Proteolytic processing of AβPP. (a) Representative Western blot of full-length AβPP and AβPP carboxy-terminal fragments, C99 and C83, in total protein cortical extracts. Full-length blots are presented in Supplementary Figure 2. Quantification of immunolabeled bands for AβPP (b), C83 (c) and C99 (d). The results (fold over control –WT-) are expressed as the mean ± SEM (n = 4). (e) BACE-1 activity. The activity of BACE-1 was determined as described in Methods. Data are the mean ± SEM (n = 4). Statistical significance was analysed by two-way ANOVA with Tukey’s post-hoc test. *p < 0.05, ***p < 0.001.