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. 2018 Mar 1;7(4):259–268. doi: 10.1002/psp4.12287

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© 2018 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Effect of baseline and time‐varying covariates on pharmacokinetic parameters (clearance (CL) and volume (V)) and pharmacodynamic parameters for suppression of luteinizing hormone (half‐maximal inhibitory concentration (IC₅₀), K_in) and spermatogenesis ( $C a v g_{50}$ ). Error bars indicate 95% confidence interval based on a nonparametric bootstrap.