Figure 2.

Prediction‐corrected visual predictive check for total testosterone obtained from 1,000 simulations stratified on dose and sampling period. Black solid points are observed concentrations. Red solid and dashed lines represent 2.5th, 50th, and 97.5th percentiles of observed data. The shaded areas indicate simulation‐based 95% confidence intervals around the median (orange) and the 2.5th and 97.5th percentiles (blue) from 1,000 simulations with the final model. Note: All subjects received 14 weekly injections of testosterone cypionate (TC) from week 2 to week 15. Intensive pharmacokinetic sampling was collected immediately postdose, at 8 hours, and then daily for 26 consecutive days after the last active TC injection (week 15).