Figure 5.

The pharmacological module driver (PMD) identification and validation. (a–g) The PMD determination in core modules by the method of “community core.” The “nc” is the number of communities, and the different shapes represent the top one node under each condition of the ncs. Nodes are considered as the PMD when the eigenvalue goes beyond the threshold (threshold = twice the median). (h) Validation of $Igf{1}_{JU-4}^D$ expression levels by real‐time polymerase chain reaction.*P < 0.05 vs. vehicle; **P < 0.01 vs. vehicle. The dotted line in h is the average expression level of the group. The ^D in the upper right corner of genes’ name means driver, and that in the lower right corner denotes its source. JA, jasminoidin; JU (jasminoidin and ursodeoxycholic acid); UA, ursodeoxycholic acid (UA).