Table 4. Association of higher-order interactions with overall ARC risk based on MDR Analysis.

No. of interacting loci	Best Interaction Model	Testing Accuracy	CVC	P for 1000 permutation Testing
ALL
1	WRN-rs11574311	0.5378	10/10	0.001
2	OGG1-rs2072668,OGG1-rs2304277	0.6193	10/10	<0.001
3	WRN-rs4733220,OGG1-rs2072668,OGG1-rs2304277	0.6199	6/10	<0.001
4	ERCC6-rs4253038,BLM-rs6496724,OGG1-rs2072668,OGG1-rs2304277	0.6266	6/10	<0.001
5	WRN-rs11574311,WRN-rs4733220,WRN-rs1801195,OGG1-rs2072668,OGG1-rs2304277	0.6273	10/10	<0.001
C
1	WRN-rs11574311	0.5637	10/10	<0.001
2	OGG1-rs2072668,OGG1-rs2304277	0.6228	9/10	<0.001
3	WRN-rs4733220,OGG1-rs2072668,OGG1-rs2304277	0.6301	4/10	<0.001
4	WRN-rs11574311,WRN-rs4733220,ERCC6-rs4838519,OGG1-rs2072668	0.6397	5/10	<0.001
N
1	BLM-rs1063147	0.5333	8/10	0.038
2	OGG1-rs2072668,OGG1-rs2304277	0.6157	10/10	<0.001
3	WRN-rs2725361,OGG1-rs2072668,OGG1-rs2304277	0.6287	9/10	<0.001
4	WRN-rs4733220, BLM-rs6496724,OGG1-rs2072668,OGG1-rs2304277	0.6042	4/10	<0.001
5	BLM-rs1063147,WRN-rs4733220,WRN-rs2725361,OGG1-rs2072668,OGG1-rs2304277	0.5595	7/10	0.01
M
1	WRN-rs11574311	0.5817	7/10	0.001
2	OGG1-rs2072668,OGG1-rs2304277	0.6051	10/10	<0.001
3	BLM-rs6496724,OGG1-rs2072668,OGG1-rs2304277	0.6319	10/10	<0.001
4	WRN-rs11574311, BLM-rs7175811,WRN-rs2725338,OGG1-rs2304277	0.6292	6/10	<0.001