Table 1.

Examples of PMT inhibitors. Examples used here are the most advanced compounds presented in the literature, to date, for which the chemical structures have been revealed.

target PMT	most advanced example compound	chemical structure	binding modality	references
DOTI L	pinometostat (EPZ-5676)		SAM-competitive	[15]
EZH2	tazemetostat (EPZ-6438)		SAM-competitive	[32]
EZH2/1	899145		SAM-competitive	[33]
PRC2 complex	SAH-EZH2 (stable peptide)		disruption of subunit interactions	[34]
PRC2 complex	A-395		disruption of subunit interactions	[35]
MLL complex	MI-503		disruption of subunit interactions	[36]
EHMT1/EHMT2	UNC0642		peptide competitive	[37]
SUV420H1/2	A-196		peptide competitive	[38]
SMYD2	EPZ033294		peptide competitive	[39]
SMYD3	EPZ031686		peptide competitive	[40]
SETD7	(R)PFI-2		peptide competitive	[41]
SETD8	UNC0379		peptide competitive	[42]
pan-type 1 PRMT	MS023		peptide competitive	[43]
PRMT3	SGC707		allosteric inhibitor	[44]
CARM1 (PRMT4)	SGC2085		peptide competitive	[45]
PRMT5	EPZ015666		peptide competitive	[46]
PRMT6	EPZ020411		peptide competitive	[47]