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(a) Interaction of GW856804X (coloured cyan) with Sirt2 (PDB ID 5D7Q). (b) Overlay of the predicted binding mode of GW856804X to Sirt2 with the co-crystallized inhibitor CHIC35 (coloured magenta) and ADPR (coloured salmon). Molecular surface is coloured according to hydrophobicity (magenta = polar region, green = hydrophobic region). Hydrogen bonds are shown as dashed lines. Water molecules are shown as red spheres.
