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Influence of linker length on inhibition of selected HDAC isoforms, data obtained from n = 1 experiments.
| compound, linker length n | HDAC1 IC50 (µM) | HDAC6 IC50 (µM) | HDAC8 IC50 (µM) |
|---|---|---|---|
| 12a, n = 3 | 24 | 4.6 | 3.4 |
| 12b, n = 4 | 3.6 | 0.9 | |
| 12c, n = 5 | 4.5 | 2.0 | |
| 12d, n = 6 | 0.9 | 0.1 | 0.1 |
| 12e, n = 7 | 0.8 | 0.3 | 2.8 |
