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Percentage inhibition of individual HDAC isoforms by 12d, values are the mean of two measurements. IC50 values were determined for HDAC1, HDAC6 and HDAC8. Owing to differences in assay conditions, absolute values are not directly comparable with table 1.
| class I isoforms |
class IIa isoforms |
class IIb and IV isoforms |
|||
|---|---|---|---|---|---|
| HDAC1 | 57%, IC50 7.3 µM | HDAC4 | 4% | HDAC6 | 99%, IC50 160 nM |
| HDAC2 | 32% | HDAC5 | 23% | HDAC10 | 44% |
| HDAC3 | 38% | HDAC7 | 9% | HDAC11 | 10% |
| HDAC8 | 90%, IC50 2.1 µM | HDAC9 | 1% | ||
