Table 3.
Univariate Analysis of Predictors for PCF Formation for All Patients Undergoing Total Laryngectomy.
| PCF (+) | PCF (‐) | p‐value | |
|---|---|---|---|
| Age (years) | 66.4 [9.7] | 64.8 [10.6] | .65 |
| Male gender (n) | 10 (100) | 60 (89.6) | .59 |
| Active smoker (n) | 6 (60) | 25 (39.7) | .31 |
| Diabetic (n) | 0 (0) | 11 (17.2) | .34 |
| COPD (n) | 6 (60) | 21 (32.8) | .16 |
| Preoperative albumin (g/L) | 31.8 [6.0] | 37.6 [4.3] | .005 |
| Salvage surgery (n) | 7 (70) | 32 (47.8) | .31 |
| High tumor stage (n) at time of surgery | 5 (50) | 49 (73.1) | .15 |
| Positive nodal stage (n) | 4 (40) | 21 (31.3) | .72 |
| Concurrent neck dissection (n) | 4 (40) | 26 (38.8) | .999 |
| Cricopharyngeal myotomy (n) | 6 (66.7) | 54 (80.6) | .39 |
| Involved surgical margins (n) | 0 (0) | 1 (1.5) | .999 |
| Primary tracheoesophageal puncture (n) | 1 (10) | 35 (52.2) | .02 |
| Postoperative hemaglobin (g/L) | 93.3 [19.0] | 106.3 [16.0] | .02 |
| Swallow day (day) | 12 {4} | 10 {3} | .06 |
| Metronidazole (n) | 7 (77.8) | 46 (79.3) | .999 |
| Anti‐skin commensal antibiotic (n) | 7 (77.8) | 27 (46.6) | .15 |
| Proton pump inhibitor (PPI) (n) | 6 (66.7) | 24 (42.1) | .28 |
| Local wound hematoma (n) | 3 (30) | 3 (4.5) | .03 |
| Values are mean [standard deviation], median {interquartile range} or n (%) | |||
| PCF = pharyngocutaneous fistula |
Bold font indicates positive correlation, italic font indicates negative correlation.