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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Exp Neurol. 2018 Mar 9;304:132–142. doi: 10.1016/j.expneurol.2018.03.006

Figure 1. Experimental Timelines, Spinal Cord Injury (SCI) Lesion, and Acute Dose Response Curve.

Figure 1

Experimental timelines for the effect of time (A) and effect of therapy (B) studies (IHC = immunohistochemistry). C. Exemplar photomicrograph of a completely transected spinal cord (Nissl and myelin stain; scale bar = 1 mm). D. Color coded schematic of spinal gray matter regions of interest used during 5-HT and MAP2 protein immunostaining assessments. E. Acute dose response on BBB score using a saline (Sal.), 0.075 mg/kg, or 0.125 mg/kg combination dose of the 5-HTR agonists quipazine and 8-OH-DPAT (Late N=7; Early N=4). Within group differences: ### different from Sal. at p<0.001, # different from Sal. at p<0.05; * different from 0.075 mg/kg at p<0.05. Across group differences: + different from Early at same dose at p<0.025. Data displayed is mean ± S.E.M.