Table 2.
Risk of death after dialysis initiation according to weight change (between eGFR of 35 mL/min/1.73 m2 and ESRD) in CRIC and AASK.
| Hazard ratio (95% CI) | ||
|---|---|---|
| Unadjusted | Adjusteda | |
| CRIC | ||
| Annualized percent weight change (N=770) | ||
| Lost weight (> 5%/y) (n=155) | 1.47 (1.12–1.94) | 1.54 (1.17–2.03) |
| Weight change ± 5% (n=570) | 1.00 (reference) | 1.00 (reference) |
| Gained (>5%/y) (n=45) | 1.31 (0.80–2.13) | 1.09 (0.66–1.79) |
| Absolute weight change (N=770) | ||
| Weight loss > 1 kg/y (n=431) | 1.64 (1.19–2.25) | 1.46 (1.06–2.02) |
| Stable weight ± 1 kg/y (n=214) | 1.00 (reference) | 1.00 (reference) |
| Gained > 1 kg/y (n=125) | 1.20 (0.79–1.84) | 1.08 (0.70–1.66) |
| AASK | ||
| Annualized percent weight change (N=333) | ||
| Lost weight (> 5%/y) (n=43) | 1.40 (0.96–2.06) | 1.56 (1.06–2.30) |
| Modest weight change (± 5%) (n=280) | 1.00 (reference) | 1.00 (reference) |
| Gained (> 5%/y) (n=10) | 1.79 (0.91–3.52) | 2.15 (1.07–4.34) |
a
For CRIC, adjusts for age at dialysis initiation, sex, race, diabetes, income category, hypertension, cardiovascular disease, smoking status ascertained at last CRIC visit available before dialysis initiation or from the 2728 form if available. For AASK, adjusts for age at dialysis initiation, sex, diabetes, income category, cardiovascular disease, and smoking status ascertained via a combination of CMS-2728 form and AASK trial and cohort data.
CRIC Chronic Renal Insufficiency Cohort; eGFR estimated glomerular filtration rate