Figure 6. TC myeloid/stromal cells expand Tfh and IFNγ-producing T cells in vivo.

B6 CD4⁺ T cells were transferred into B6.Rag or TC.Rag mice and analysis was conducted one week later in recipient mice. A. Numbers of total CD4⁺ T cells in the spleen and kidneys. Frequencies and numbers of splenic CD69⁺CD4⁺ T cells (B), Treg (C, CD4⁺FOXP3⁺) and Tfh (D, CD4⁺CXCR5⁺PD-1⁺FOXP3⁻) cells. Frequencies and numbers of IFNγ⁺ (E–F) and IL-17A⁺ (G–F) CD4⁺ T cells in the spleen and kidneys. Data represents n = 5 mice, expressed as means ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001.