Figure 2.

Activated JNK in cardiac-specific inducible MKK7D young mice leads to up-regulated CaMKIIδ. Immunoblotting images and summarized data showing markedly activated JNK (A) but preserved cardiac function (EF and FS); (B) in MKK7D mice (MKK7D⁺-Tx) with tamoxifen-induced expression of the constitutively active upstream JNK activator MKK7D compared with MKK7D negative littermates treated with tamoxifen (MKK7D^--Tx). (C) Immunoblotting images and pooled data indicating up-regulated CaMKIIδ protein expression in tamoxifen-treated MKK7D mice compared with that of controls.