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. 2018 Mar 21;20(5):411–424. doi: 10.1016/j.neo.2018.02.005

Figure 3.

Figure 3

POH1 siRNA intratumoral injection inhibits tumor proliferation. Each nude mouse was implanted with relative cells (QGY-7701, EC109, or HCT116), and 10 days later, mice with each cell line xenograft were injected with POH1 siRNA (30 μg) or scrambled siRNA twice a week. The tumor size was measured with digital calipers before the injection. (A) QGY-7701 cells were used for xenograft. The tumor volume (A1) and weight (A2) were measured after the mice were sacrificed. Representative images of the xenograft are shown (A3). (B) EC109 cells were used for xenografts. The tumor volume (B1) and weight (B2) were measured after the mice were sacrificed. Representative images of the xenograft are shown (B3). (C) HCT116 cells were used for xenograft. The tumor volume (C1) and weight (C2) were measured after the mice were sacrificed. Representative images of the xenograft are shown (C3). (D) TUNEL assay for cell apoptosis in POH1 siRNAs or scrambled siRNA groups. (E) Apoptotic index was counted according to the apoptotic cell number under three randomly selected fields. All *P<.05 and **P<.01.