Table 1.
Univariate and Multivariate Analyses of Clinicopathological and POH1 Expression for Overall Survival in HCC Patients (n=461).
| Variables | Univariate Analysis |
Multivariate Analysis |
||
|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | |
| Age (<49 vs. ≥49 years) | 0.884 (0.736-1.062) | .188 | ||
| Gender (female vs. male) | 1.082 (0.797-1.469) | .613 | ||
| HBV (positive vs. negative) | 1.186 (0.927-1.519) | .175 | ||
| Tumor size (<5 vs. ≥5 cm) | 1.562 (1.248-1.955) | .000 | 1.251 (0.975-1.605) | .078 |
| Tumor multiplicity (single vs. multiple) | 1.334 (1.105-1.611) | .003 | 0.996 (0.796-1.247) | .971 |
| Tumor capsule (absent vs. present) | 0.707 (0.585-0.855) | .000 | 0.890 (0.728-1.089) | .258 |
| Liver cirrhosis (yes vs. no) | 0.674 (0.530-0.858) | .001 | 0.754 (0.586-0.970) | .028 |
| AFP (<20 vs. ≥20 ng/ml) | 1.514 (1.217-1.885) | .000 | 1.317 (1.050-1.652) | .017 |
| Vascular invasion (yes vs. no) | 2.109 (1.612-2.529) | .000 | 1.431 (1.115-1.837) | .005 |
| Tumor differentiation | 1.377 (1.145-1.657) | .001 | 1.211 (1.002-1.464) | .048 |
| TNM (I-II vs. III-IV) | 1.836 (1.523-2.213) | .000 | 1.380 (1.067-1.784) | .014 |
| POH1 expression (low vs. high) | 1.277 (1.055-1.545) | .012 | 1.229 (1.013-1.491) | .036 |
AFP, a-fetoprotein; HBsAg, hepatitis B surface antigen; HR, hazard ratio; CI, confidence interval.