Fig. 1. Structure of CAM4066 and pro-CAM4066. Zwitterionic elements are coloured in dark green, amide bonds in blue and the difference between CAM4066 and its prodrug highlighted in purple. The interaction between CAM4066 and the highly conserved Lys68 is shown as red dashed line. The flexible linker is circled in orange. The αD pocket and ATP binding site are reported as black curves.
