Fig. 4. Cross sections of the αD and ATP pockets: first and second rows are lateral views and last row is a view from the top. The water channel is highlighted in blue and the hydrophobic pocket in green for complexes that are not making the most of the space available. (a) Co-crystal structure of 1 with CK2α (PDB: ; 5CSH); (b) co-crystal structure of 2 with CK2α (PDB: ; 5ORH); (c) co-crystal structure of 3 with CK2α (PDB: ; 5ORJ); (d) co-crystal structure of 14 with CK2α (PDB: ; 5OTR); (e) co-crystal structure of 15 with CK2α (PDB: ; 5OTZ).